TR - FRET Assay Kit for Immunity & Cancer

The KeyTec® TR-FRET GDP loaded KRAS[G12D]/SOS1 Binding Assay kit is designed for measurement of the interaction between KRAS[G12D] and SOS1 proteins. It is based on sandwich immunoassay model and utilizes TR-FRET technology, known for its ease of use, homogeneity (no wash), low background, high sensitivity, high accuracy.

The KeyTec® TR-FRET GDP loaded KRAS[G12D]/RAF1 Binding Assay kit is designed for measurement of the interaction between KRAS[G12D] and RAF1 proteins. It is based on sandwich immunoassay model and utilizes TR-FRET technology, known for its ease of use, homogeneity (no wash), low background, high sensitivity, high accuracy.

KeyTec® TR-FRET PD1/PD-L1 Binding Assay Kit is designed for the quantitative measurement of the interaction between human PD1 and PD-L1 proteins. This kit provides a Tag1-PD-L1 protein, a Tag2-PD1 protein, an anti-tag1 antibody labeled with KeyTec® TR-FRET Solar Eu* 1 (mAb anti-Tag1 - Solar Eu) ,an anti-tag2 antibody labeled with KeyTec® TR-FRET LA* 2 (mAb anti-Tag2 - LA) and other detection reagents. These components enable the high-throughput screening of small molecule inhibitors, peptides, or antibody blockers.

KeyTec® TR-FRET human cereblon binding kit is designed for the binding analysis of cereblon ligands/inhibitors to wild-type human cereblon. This kit provides a tag1- cereblon/DNA damage-binding protein 1 complex ( Tag1-CRBN/DDB1 ), a Thalidomide-HX*¹ (a cereblon inhibitor), an anti-tag1 antibody labeled with KeyTec® TR-FRET Solar Eu*² (mAb anti-Tag1 - Solar Eu) and other detection reagents. These components enable the high-throughput screening of cereblon ligands/inhibitors.

This assay is based on a competitive immunoassay method using KeyTec® TR-FRET technology, offering a simple, rapid, highly specific and sensitive, as well as reproducible detection process.

KeyTec® TR-FRET human von Hippel−Lindau(VHL) binding kit is designed for the binding analysis of VHL ligands/inhibitors to wild-type human VHL. This kit provides a tag1- VHL/Elongin C/Elongin B protein complex ( Tag1-VCB complex ), a VHL ligand-LA*¹ (CAS#1948273-02-6), an anti-tag1 antibody labeled with KeyTec® TR-FRET Solar Eu*² (mAb anti-Tag1 - Solar Eu) and other detection reagents. These components enable the high-throughput screening of VHL ligands/inhibitors. This assay is based on a competitive immunoassay method using KeyTec® TR-FRET technology, offering a simple, rapid, highly specific and sensitive, as well as reproducible detection process.