IL-17 Signaling Pathway – A Hot Target in Autoimmune and Inflammatory DiseasesThe interleukin-17 (IL-17) family is a critical node in the body's immune regulatory network, with physiological func...
The SMARCA2 gene encodes a protein called BRM (or SNF2-alpha), which is one of the core catalytic subunits of the critical chromatin-remodeling complex (SWI/SNF complex) within cells. This gene and it...
The PD-1 signaling pathway is one of the core mechanisms mediating tumor immune evasion. Upon binding to its ligands (PD-L1/PD-L2), PD-1 activates the phosphatases SHP-1/2, truncating T-cell activatio...
Transcriptional enhancers are short regulatory DNA elements that recruit BRD4, RNA polymerase II (RNA Pol II), transcription factors, and coregulators to enhance transcription of nearby genes by formi...
In the fields of fundamental immunology research and drug discovery, cytokines serve as crucial signaling molecules that reveal physiological and pathological processes.TNFαA classic pro-inflammatory...
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