BACKGROUNDIn the field of drug discovery, Signal Transducer and Activator of Transcription 6 (STAT6) has long been a challenging "undruggable" target for countless scientists. As the core do...
The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway is a cytosolic DNA-sensing pathway that plays a crucial role in innate immune responses. When cGAS recogniz...
BackgroundIn the field of targeted cancer therapy, PROTAC (Proteolysis-Targeting Chimera) technology is leading a revolutionary paradigm shift. Unlike traditional small molecule inhibitors, PROTAC mol...
Background PROTAC Technology: A Revolutionary Breakthrough from "Undruggable" to "Druggable" One of the most remarkable advantages of Proteolysis Targeting Chimera (PROTAC) techn...
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