Kinases play important roles in regulating cellular functions, including cell proliferation, apoptosis, subcellular translocation, inflammation and metabolism.
Mutations and dysfunctions of kinases are a significant contributing factor to a vast array of diseases, including cancer, autoimmune disorders and neurodegenerative conditions.
Consequently, kinases have emerged as a crucial area of focus for drug research, with over 90 new kinase-related drugs having been approved by the FDA.
KeyTec® ERN1, N-GST, C-Flag is a recombinant protein with a GST tag at the N-terminus and a Flag tag at the C-terminus. The protein was purified using GST affinity chromatography. This ERN1 protein batch has high enzymatic activity in the ADP-Glo assay.
For KeyTec® kinase protein products, each batch of protein is subjected to a series of rigorous validation procedures to obtain data such as purity, monomer/polymer morphology, enzyme activity information, positive compound validation information, and so forth.
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