Kinases play important roles in regulating cellular functions, including cell proliferation, apoptosis, subcellular translocation, inflammation and metabolism.
Mutations and dysfunctions of kinases are a significant contributing factor to a vast array of diseases, including cancer, autoimmune disorders and neurodegenerative conditions.
Consequently, kinases have emerged as a crucial area of focus for drug research, with over 90 new kinase-related drugs having been approved by the FDA.
KeyTec® TYK2(JH2), N-His-3C recombinant protein with N-terminal 8×His tag and 3C protease cleavage site was purified by Ni-NTA affinity chromatography and confirmed to be monomeric in solution by SEC-HPLC analysis. The TYK2(JH2) recombinant protein showed high enzymatic activity in FP assay.
For KeyTec® kinase protein products, each batch of protein is subjected to a series of rigorous validation procedures to obtain data such as purity, monomer/polymer morphology, enzyme activity information, positive compound validation information, and so forth.
English
